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Ubiquitin tag for sperm mitochondria

Posted on April 18, 2021 by Jordan

Mitochondrial sequences

Detailed sample and variant quality control are described in the supplementary methods. In special consideration of mtDNA-CN as the GWAS phenotype, we also removed variants within “NUMTs”,

Imputed genotypes (version 3) for 488,264 UKBiobank participants were downloaded through the European Genome Archive 131-CR1101
  • which refer to regions of the nuclear genome
  • that exhibit homology to the mitochondrial genome
  • Due to past transposition of mitochondrial sequences.

After quality control, 359,689 British, 10,598 Irish, 13,189 Other White, 6,172 South Asian, and 6,133 African samples had suitable array-based mtDNA-CN estimates for subsequent GWAS testing.

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