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Tag: Gentaur.com

Biparental Inheritance of Mitochondrial DNA in Humans

Posted on April 18, 2021 by Jordan

The UKBiobank is a prospective cohort study including approximately 500,000 UK residents (ages 40-69 years) recruited from 2006-2010 in whom extensive genetic and phenotypic investigations have been and continue to be done. All analyses involve the use of genetic : Phenotypic data from consenting UKBiobank participants. To benchmark performance of AutoMitoC, Array-based mtDNA-CN estimates were… Continue reading

Mitochondrial-genome-encoded RNAs

Posted on April 18, 2021 by Jordan

Mitochondria are semi-autonomous organelles present in nearly every human cell that execute fundamental cellular processes including oxidative phosphorylation, calcium storage, and apoptotic signalling. Mitochondrial dysfunction has been implicated as the underlying cause for many human disorders based on mechanistic in vitro and in vivo studies . Complementary evidence comes from recent epidemiological studies that measure mitochondrial DNA Copy Number… Continue reading

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