The UKBiobank is a prospective cohort study including approximately 500,000 UK residents (ages 40-69 years) recruited from 2006-2010 in whom extensive genetic and phenotypic investigations have been and continue to be done. All analyses involve the use of genetic : Phenotypic data from consenting UKBiobank participants. To benchmark performance of AutoMitoC, Array-based mtDNA-CN estimates were… Continue reading
Tag: Elisa Kit
Mitochondrial DNA deletions are associated with non-B DNA conformations
To interrogate mtDNA-CN as a potential determinant of human diseases, we performed extensive genetic investigations in up to 395,781 participants from the UKBiobank study. We first developed and validated a novel method for biobank-scale mtDNA-CN investigations that leverages SNP array intensities, called “AutoMitoC”. Various analyses were then conducted to build on previous publications regarding the… Continue reading
Mitochondrial DNA and rate metabolic
While previous studies demonstrate that mtDNA-CN is a biomarker of mitochondrial activity associated with various diseases, evidence suggests that it may also play a direct and causative role in human health and disease. Forle, in cases of mtDNA depletion syndrome, wherein rare defects in nuclear genes responsible for replicating and/or maintainingNA lead to deficient mtDNA-CN.… Continue reading