Skip to content

MITOchondrial DYNamics variation portal

The ACO2 gene homepage – Variation OPA1 mutation database

Menu
  • Home
  • Polyclonal
  • Isotype
  • Medium
  • Distributors
  • Serum
  • Vector
  • antigen
  • Assay
  • Contact Us
Menu

Paternal inheritance of mitochondrial DNA in mice

Several investigations for mtDNA-CN

While have been performed, the present study represents the most comprehensive genetic assessment to date Ryan Joseph. Notably, Hagg et al. (2020) recently conducted a GWAS for mtDNA-CN in 295,150 UKBiobank participants and identified 50 common loci. However, the method developed by Hagg et al. (2020) calibrated SNP probe intensities based on association with whole-exome sequencing read depths, which may limit the convenience of the method.

In contrast, AutoMitoC only necessitates array probe intensities and does not require any secondary genetic measurements (WES or otherwise) for calibration. In addition, AutoMitoC exhibits superior concordance with WES-based estimates (Hagg r=0.33; AutoMitoC r=0.45)

When the tip of the swab reaches the posterior wall of the
nasopharyngeal cavity, gently rotate it several times. (Collect as much secretion as possible) 02-NATSARS(COV2)ST

, which was validated in an independent dataset with gold standard qPCR measurements. Further, Hagg et al. (2020) restricted genetic analyses to unrelated European individuals, whereas we incorporated ∼100,000 additional individuals and demonstrated consistency in genetic effects between Europeans and non-Europeans (r ≥ 0.88). The greater sample size in combination with more accurate mtDNA-CN estimates may explain the 44% increase in identified common loci (72 vs 50).

In the present study we included exploration of the role of rare variants through ExWAS and, notably, Mendelian Randomization analyses to assess disease contexts whereby mtDNA-CN may represent a causal mediator and a potential therapeutic target.

Recent Posts

  • NCBI References of Lab ELISAs
  • VWR alternatives of Lab recombinants
  • Sigma alternatives of Lab Assays
  • NIH References of Lab polyclonals
  • Compare recombinant lab reagents for research

Recent Comments

    Categories

    • antigen
    • Assay
    • Enzyme
    • ethidium
    • Isotype
    • Medium
    • Polyclonal
    • Recombinant
    • rna
    • Uncategorized
    July 2025
    M T W T F S S
     123456
    78910111213
    14151617181920
    21222324252627
    28293031  
    « Feb    

    Categories

    • antigen
    • Assay
    • Enzyme
    • ethidium
    • Isotype
    • Medium
    • Polyclonal
    • Recombinant
    • rna
    • Uncategorized

    Recent Posts

    • NCBI References of Lab ELISAs
    • VWR alternatives of Lab recombinants
    • Sigma alternatives of Lab Assays
    • NIH References of Lab polyclonals
    • Compare recombinant lab reagents for research
    © 2025 MITOchondrial DYNamics variation portal | Powered by Superbs Personal Blog theme