A team of CNRS 6214/INSERM 1083

Research

Mitochondria are membrane-enclosed organelles found in most eukaryotic cells. These organelles are sometimes described as « cellular power plants » because they generate most of the cell’s supply of adenosine triphosphate (ATP), used as a source of chemical energy. In addition to supplying cellular energy, mitochondria are involved in other tasks such as signaling, cellular differentiation, cell death, as well as the control of the cell cycle and cell growth. Mitochondria have been implicated in several human diseases, including mitochondrial disorders and cardiac dysfunction, and may play a role in the aging process.

Our team is fully dedicated to mitochondrial research through the following three main axes.

We have produced more than one hundred scientific articles. You will find a large part of our publications in PubMed using this query.

Dynamics & bioenergetics

Biobank of fibroblasts to serve as models in the context of diseases due to defective mitochondrial dynamics – Characterization of the molecular and biochemical processes involved in the mitochondrial dynamics of the diseases – Visualization of mitochondrial dynamics – Investigation of bioenergetics in mouse models of ADOA/OPA1 and CMT2A/MFN2 – Bioenergetic metabolism of a mouse model reproducing the ADOA phenotype. FULL TEXT

Translational research & diseases

Determination of phenotype-genotype correlations and the definition of new clinical entities – Representation of the spectrum of OPA1 mutations  – Characterization of diseases associated with OPA1 and mtDNA mutations – The mitodyn.org portal of databases of genes incriminated in disorders involving mitochondrial dynamics and bioenergetics – Various translational research activities related to mitochondria and energetic metabolism. FULL TEXT

Genetics & therapeutics

Mutations of mitochondrial genome (mtDNA) – New strategy for the rapid identification of heteroplasmic mtDNA mutations – Heteroplasmic neuronal cybrid cells harboring known deleterious mtDNA mutations – Mitochondrial genetic variations in recovery from stroke and in longevity – Inter-individual variability – Endothelial dysfunction – In vivo estrogen replacement – How endogenous estrogen and estrogen-related therapies impact vascular function. FULL TEXT